This program seems to be compact enough to not conflict with anything you might have going on. It doesn't fight with my antivirus program, which is a relief.
I do like that it reminds me to clean my machine, rather than just doing that on its own without my input or choice.
I've had CCleaner for a very long time and avail myself of most of its features on a regular basis. The result for me is that I have a machine that is eight years old and still runs like a champ, same as the day I finished the build.